Thumbnail imageDiffuse Nodular SB Mucosa Lymphangiectasia

  • Primary(anomalous lymphatic dilitation) or secondary(dilitation from lympatic obstruction) forms are indistinguishable radiographically. Cause thickening of SB wall/folds and nodular mucosal pattern
  • DDX diffuse nodular SB mucosa

Tumor- lymphoma, mets melanoma
Infection/Inflammatory – Whipple, Crohn, Histo, nodular lymphoid hyperplasia, amyloid
Congenital – waldenstorm’s macroglobulinemia, polyposis
Metabolic
Vascular – lymphangiectasia, ischemia(edema/pneumatosis)
Other - Mastocytosis

Lymphoma
Peutz – Jeghers
Nodular Lymphoid hyperplasia
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Crohn’s disease
Amyloidosis
Histoplasmosis
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  • Waldenstrom’s macroglobulinemia – idiopathic plasma cell dyscrasia. Associated HSM, lymphadenopathy, bleeding, anemia
  • Mastocytosis – mast cell proliferation bone, skin, GI tract. Associated symptoms from release of histamine from mast cells
  • Nodular lymphoid hyperplasia – can be a normal finding in children. Adults, more commonly associated with infection or inflammatory process
Duke DDX Multiple SB Masses
Polyposes
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  • Benign neoplasms – hemangioma, leiomyoma, neurofibroma
  • FB
  • Malignant neoplasms – carcinoid, lymphoma, mets
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