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Comparison of Dose-escalated Hypofractionated IMRT and Standard IMRT for Localized Prostate Cancer

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According to a study published in the International Journal of Radiation Oncology, Biology, Physics (Red Journal), which also serves as the official scientific journal of the American Society for Radiation Oncology (ASTRO); dose-escalated intensity modulated radiation therapy (IMRT) in combination with a moderate hypofractionation regimen (72 Gy in 2.4 Gy fractions) can safely treat patients with localized prostate cancer with limited grade 2 or 3 late toxicity.

Prior randomized clinical trials have demonstrated that dose-escalated radiation therapy enhances and improves prostate cancer control as opposed to lower-dose standard radiation therapy.

Traditional fractionation of dose-escalated radiation therapy (1.8 or 2 Gy fractions) can take up to nine weeks to complete, whereas hypofractionated radiation therapy can facilitate a higher biologically effective dose over a shorter period of time (six weeks) and has the potential to increase prostate cancer control without increasing toxicity. Yet, there exists limited data on the late toxicity of moderate hypofractionated regimens for prostate cancer. This randomized trial from the University of Texas MD Anderson Cancer Center juxtaposes the late toxicity outcomes of men with localized prostate cancer treated with either conventionally fractionated IMRT (CIMRT) or dose-escalated hypofractionated IMRT (HIMRT).

Men with organ-confined prostate cancer were registered in this institutional review board-approved trial from January 2001 to January 2010 and were randomized to receive either CIMRT (75.6 Gy in 1.8 Gy fractions over eight-and-a-half weeks) or HIMRT (72 Gy in 2.4 Gy fractions over six weeks). Qualified patients had biopsy, proven prostate adenocarcinoma; good performance status; stage T1b-T3b disease; a prostate-specific antigen (PSA) ≤20 ng/ml; a Gleason score <10; and no clinical, radiographic or pathologic evidence of nodal or bone metastasis. Patients with stage cT3c or cT4 disease, a history of prior pelvic radiation therapy, or who received more than four months of hormone ablation therapy with previous or planned radical prostate surgery and with simultaneous active malignancy other than nonmetastatic skin cancer or early-stage chronic lymphocytic leukemia were not eligible for the trial.

The average age of the patient group was 68. Of the 203 patients analyzed in the study, 72 percent had stage T1 disease (146) and 89 percent had a PSA All patients were treated with static-field IMRT. One hundred and one men were administered CIMRT and 102 men received HIMRT. Physician-reported toxicity was assessed for all patients during treatment and at each follow-up visit. Following completion of radiation therapy, follow-up was performed on a six month basis for the first two years post-treatment, and annually thereafter. Average follow-up was six years.

Localized-Prostate-CancerLate gastrointestinal (GI) and genitourinary (GU) toxicity were analyzed in this study, starting 90 days post-treatment, using modified Radiation Therapy Oncology Group toxicity grading. In the CIMRT arm, 17 percent experienced grade 1 GI toxicity, 4 percent experienced grade 2 GI toxicity and 1 percent experienced grade 3 GI toxicity. In the HIMRT arm, 26 percent experienced grade 1 GI toxicity, 9 percent experienced grade 2 GI toxicity and 2 percent experienced grade 3 GI toxicity. There was a numeric increase in the absolute frequency of late GI toxicity for men treated with HIMRT, but the difference was not statistically significant. The five-year actuarial grade 2 or 3 late GI toxicity was 5.1 percent (95 percent Confidence Interval (CI)) for patients treated with CIMRT and 10 percent for patients treated with HIMRT. The increase in late GI toxicity for men receiving HIMRT was the result of moderate and high radiation dose to a larger proportion of the rectum, which suggests that more stringent dose constraints for the rectum may result in lower late GI toxicity for those patients.

Furthermore, there was not a statistically significant difference in the absolute frequency of late GU toxicity in men treated with CIMRT or HIMRT. In the CIMRT arm, 15 percent experienced grade 1 GU toxicity, 14 percent experienced grade 2 GU toxicity and 1 percent experienced grade 3 GU toxicity. In the HIMRT arm, 10 percent experienced grade 1 GU toxicity and 15 percent experienced grade 2 GU toxicity; no patients reported grade 3 GU toxicity. The five-year actuarial grade 2 or 3 late GU toxicity was 16.5 percent (95 percent CI) for patients treated with CIMRT and 15.8 percent for patients treated with HIMRT.

"These results demonstrate that the length of radiation treatment for prostate cancer can be safely decreased to six weeks (from eight-and-a-half weeks) by delivering larger daily doses of radiation without increasing the urinary and bowel effects. Decreasing the length of treatment decreases the cost and is more convenient for patients," said co-author of the study and assistant professor in the Division of Radiation Oncology at the University of Texas MD Anderson Cancer Center in Houston, Karen E. Hoffman, M.D.


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