Nasopharyngeal Carcinoma Patient Response to RT Calculated

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Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) affects cells lining the nasopharynx. The bulk of NPC cases can be cured by radiation therapy (RT), however, 20% are resistant to radiation treatment.

In the issue of the Journal of Clinical Investigation, Yu-Sun Chang and colleagues at Chang Gung University aimed to find a way to forecast which individual cases of NPC would be sensitive to radiation therapy.

In their research titled, “Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance,” the authors compared the levels of various serum factors between NPC patients that responded to radiation therapy and patients that were resistant to therapy.

 Patients who did not respond to radiation therapy had higher serum levels of the IL-6 family cytokine leukemia inhibitory factor (LIF), and that LIF levels were predictive of NPC patient response to radiation therapy.

The researchers further showed that LIF itself triggers NPC.

In an accompanying commentary, Micah Luftig from the Duke University School of Medicine discusses the implications of LIF as a predictor of NPC resistance to radiation therapy.


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