FFR, iFR Detect Hemodynamic Changes Following PCI

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percutaneous coronary intervention PCI

Immediate wave-free radio and fractional flow reserve showed identical abilities for detecting stenosis significance following percutaneous coronary intervention (PCI) in a study published in the journal Heart.

Researchers conducted the potential study to evaluate instantaneous wave-free ratio (iFR) with FFR and whole cycle Pd/Pa as techniques to detect improvement in stenosis significance following PCI.

Qualified participants were penciled in for PCI and had FFR ≤0.8. There were 120 coronary stenoses in 112 patients gathered from the U.K. and US coronary cath labs.

Researchers calculated intracoronary pressures when idle and during adenosine-mediated vasodilatation before and after PCI.

Baseline data revealed that the average age of the patients was 63 years. The population was 84% men and 39% smokers, while 33% had diabetes.

Quantitative coronary angiography presented an average diameter stenosis of 68%.

Results prior to PCI showed an average FFR of 0.66 in comparison with an average iFR of 0.75 and an average Pd/Pa of 0.83.

PCI experienced an increase in FFR to 0.89, in accordance with an increase in iFR to 0.94 and in Pd/Pa to 0.96 (P<.001 for all three).

Similar post-intervention increases were noted for iFR (0.2) and FFR (0.22; P=.25).

The changes in both FFR and iFR were considerably greater than the change in resting Pd/Pa (0.13; both P<.001).

Based on the results, patients with increased occurrence of diabetes, hypertension, and other risk factors for microcirculatory disease experienced comparable incremental changes.

The researchers said iFR and FFR have the capability to detect hemodynamic changes resulting from PCI. They added that these two approaches are connected to a larger dynamic range than Pd/Pa.

IFR might be used to objectively document improvement in coronary hemodynamics following PCI in a similar manner to FFR,” the researchers concluded.

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