Obstetric Ultrasound

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(3rd trimester, screening US)
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Holoprosencephaly

  • Coronal image of the fetal brain shows the cerebral cortex (arrows) is fused across the midline and the falx is absent. Thalami are also partially fused
  • Commonly associated with abnormal karyotype (often trisomy 13), as well as midline facial clefts, hypotelorism, and proboscis
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